Regina is a genus of colubrid snakes known as crayfish snakes, named after their primary choice of diet. The genus consists of four species which are found predominantly in the southern and eastern United States.
- striped crayfish snake, Regina alleni (Garman, 1874)
- Graham's crayfish snake, Regina grahamii Baird & Girard, 1853
- glossy crayfish snake, Regina rigida (Say, 1825)
- queen snake, Regina septemvittata (Say, 1825)